Lupus Australia, Queensland Inc

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What Is Lupus?

SLE (Systemic Lupus Erythematosus), or simply lupus, is a treatable, chronic, inflammatory, auto-immune disease. When you have lupus, your body's defence mechanism - your immune system goes into overdrive and starts to attack certain body organs. Lupus is not contagious or infectious or imagined.

What are the symptoms?

Lupus has many symptoms which take an irregular course of remissions (symptom-free cycles) and flare-ups.
Symptoms may include extreme fatigue, joint and muscle pain, facial rashes, headaches, fever, sun
sensitivity, hair loss, depression, mouth ulcers and eye problems. Like many people with lupus, you may often look perfectly healthy, but feel terrible.

What is the cause?

Until research scientists fully understand how the immune system works, the cause of lupus will remain unknown.However, lupus may be triggered by puberty, exposure to sunlight, menopause, childbirth, trauma, certain medications and viral infection.

What now

Lupus will impact your life and the lives of your family and friends. Lupus is very individual and uncertain. This adds to the stress of coping with and managing this disorder. You need to remain positive, maintain a sense of humour, learn about your illness, participate in medical management and balance your lifestyle. But you are not alone

And the cure

Lupus is a chronic illness - it will never go away. To date, there is no cure for lupus. But this does not mean that you will never be well again, or that the pain will never go away. You will probably require continual medical care and/or medication. Of course, like anyone else, you will need to balance your lifestyle and your diet.

With today's technology - improved diagnostic tests and medication - you can anticipate a near normal life span. However, having lupus means adjusting your lifestyle.




Study of Umbilical Cord Blood-Derived Stem Cells for Lupus Therapy

Human umbilical cord blood-derived mensenchymal stem cells (uMSCs) have been found to offer benefits for treating lupus nephritis (LN) when transplanted into mouse models of systemic lupus erythematosus (SLE). SLE is an autoimmune disease with “myriad immune system aberrations” characterised by diverse clinical conditions, including LN, a leading cause of morbidity and mortality for patients with SLE. The beneficial results were reported in a study by Taiwanese researchers published in the current issue of Cell Transplantation (20:2).

According to corresponding author Dr. Oscar K. Lee of the National Yang-Ming University School of Medicine, MSCs have been shown to possess immune-modulatory capabilities and can alleviate immune responses by inhibiting inflammation as well as the function of mature and immature immune system T cells. Seeking to explore the therapeutic effects of uMSCs in treating LN, their study systemic immune diseases closely resembling SLE in humans.

We found that uMSC transplantation markedly delayed the deterioration of renal function, reduced certain antibody levels, alleviated changes in renal pathology and the development of proteinuria – the presence of excess protein serum in the urine and a sign of renal damage,” said Dr. Lee.

The positive difference in survival rate for mice treated at two months of age compared with mice treated at six months of age, led the researchers to conclude that early uMSC transplantation may be most efficacious. The researchers also deduced that their findings favored the use of allogenic (other-donated) rather than autologous (self-donated) MSCs for SLE treatment, which would make sense with an autoimmune disorder.

The therapeutic effects demonstrated in this pre-clinical study support further exploration of the possibility of using uMSCs from mismatched donors in LN treatment,” concluded Dr. Lee.

The ability of uMSCs to reduce inflammation means that they are likely to be of use in the treatment of autoimmune disorders and this study supports that reasoning and, in this case, also advocates the use of non-self cells,” said Dr. David Eve, associate editor of Cell Transplantation and an instructor at the University of South Florida Centre of Excellence for Aging and Brain Repair.

Retrieved April 13, 2011 from


Lupus Booklet

A nineteen page booklet filled with stories and poems written by people who have lupus

Including a foreword written by Dr Carola G Vinuesa and Dr Matthew Cook, research scientists who are looking at the causes of lupus.

Contact us if you are interested in purchasing this interesting little book

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